Current Concepts and Controversies in Orthopaedic Oncology

Angioleiomyoma of the Hand: A Case Series and Review of the Literature

Background: Angioleiomyomas are rare tumors arising from vascular tissue that can occasionally present in the hand.Reports of angioleiomyomas in this location are highly limited. Here, we describe the presentation and outcomes of aseries of cases of angioleiomyomas.Methods: A retrospective case review of five patients with angioleiomyomas arising in the hand was performed. Pat...

Controversies in Obesity Treatment

The markedly high prevalence of obesity contributes to the increased incidence of chronic diseases, such as diabetes, hypertension, sleep apnea, and heart disease. Because of high prevalence of obesity in almost all countries, it has been the focus of many researches throughout the world during the recent decades. Along with increasing researches, new concepts and controversies have been emerge...

Lung cancer screening: a new era.

Screening is always an issue that generates a great deal of emotion, as recently seen with the controversies surrounding mammography and prostate-specific antigen (PSA) testing. The role of screening is to detect cancers early in asymptomatic individuals, with a goal of facilitating timely intervention to decrease morbidity and mortality. The key words/concepts in the foregoing sentence are “as...

Selectins and their ligands: current concepts and controversies.

Adjuvant trastuzumab: progress, controversies, and the steps ahead

The major breast cancer story of 2005 was trastuzumab, a monoclonal antibody directed against the Her-2 oncoprotein, and how it greatly improves outcomes for women with HER2-positive early-stage breast cancer. With early results showing that use of the drug can prevent roughly one half of relapses, adjuvant trastuzumab has been approved, funded, and accepted as the standard of care in many Cana...